1 2 Clock Genes and Metabolic Disease 3 4 5
نویسندگان
چکیده
منابع مشابه
NIGHT SHIFT WORK HAS BEEN ASSOCIATED WITH A NUMBER OF NEGATIVE HEALTH OUTCOMES INCLUDING CARDIOVASCULAR AND GASTROINTESTINAL disease,1 disturbances of the metabolic syndrome,2 reproductive difficulties
NIGHT SHIFT WORK HAS BEEN ASSOCIATED WITH A NUMBER OF NEGATIVE HEALTH OUTCOMES INCLUDING CARDIOVASCULAR AND GASTROINTESTINAL disease,1 disturbances of the metabolic syndrome,2 reproductive difficulties including spontaneous abortion,3 and increased risk of cancer.4 The rapid reorientation in the sleep/wake schedule brought about by night shift work results in a misalignment between the output o...
متن کاملMetabolic Rate Calibrates the Molecular Clock: Reconciling Molecular and Fossil Estimates of Evolutionary Divergence
2 Observations that rates of molecular evolution vary widely within and among lineages have cast doubts upon the existence of a single " molecular clock " (1, 2). Differences in the timing of evolutionary events estimated from genetic and fossil evidence have raised further questions about the existence of molecular clocks and their use (3, 4). Here we present a model of nucleotide substitution...
متن کاملTuning in to the rhythm of clock genes in skeletal muscle★
Circadian rhythms and metabolic homeostasis are closely entangled biological processes. Clock genes refer to a group of genes which regulate a variety of biological responses through their periodic expression. Genes encoding the core clock mechanism include the positive transcriptional regulators brain and muscle Arnt-like protein-1 (BMAL1) and circadian locomotor output cycles kaput protein (C...
متن کاملInsulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription
Circadian rhythms are responsive to external and internal cues, light and metabolism being among the most important. In mammals, the light signal is sensed by the retina and transmitted to the suprachiasmatic nucleus (SCN) master clock [1], where it is integrated into the molecular oscillator via regulation of clock gene transcription. The SCN synchronizes peripheral oscillators, an effect that...
متن کاملThe hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.
Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NA...
متن کامل